The Science Behind Magnesium

The Science Behind Magnesium Infusions: Why Your Body Might Thank You

Magnesium is often called the “master mineral” - and for good reason. It supports hundreds of vital processes in the body, yet many people don’t get enough. It is even used worldwide in hospitals to treat arrythmias, pre-ecclampsia, respiratory distress, and migraines [8]! While magnesium supplements are common, IV magnesium infusions offer superior absorption and faster results, especially for those with deficiencies or specific health concerns.

Let’s explore the science-backed benefits of magnesium and why IV delivery is gaining popularity in both wellness and clinical settings.

Why Magnesium Matters

Magnesium is involved in more than 300 enzymatic reactions, influencing everything from muscle function to nerve transmission to energy production [1]. It helps:

• Regulate muscle and nerve function

• Maintain vascular health & healthy blood pressure

• Support glucose metabolism

• Promote strong bones and DNA repair

• Reduce inflammation

Yet, up to 75% of people in the U.S. are not meeting the recommended daily intake, often due to poor dietary habits, stress, medications, and medical conditions that impair absorption [2].

Why Infuse Instead of Ingest?

Oral magnesium supplements can be helpful - but they’re not always effective due to:

1. Low Bioavailability: Many oral forms (like magnesium oxide) have absorption rates as low as 4% [3].

2. GI Tolerance: Higher doses often lead to diarrhea or cramping, making it difficult to reach therapeutic levels.

3. Malabsorption Issues: Conditions like IBS, Celiac, or chronic stress can impair gut absorption of magnesium [4].

By contrast, IV magnesium bypasses the digestive system, delivering 100% bioavailability directly into the bloodstream - making it ideal for acute or chronic deficiencies [5].

Evidence-Based Benefits of Magnesium

Reduced Anxiety & Improved Mood

Magnesium regulates neurotransmitters like GABA and serotonin. One meta-analysis found that magnesium supplementation significantly reduced symptoms of anxiety, particularly in people with mild to moderate anxiety [6].

Better Sleep Quality

Low magnesium is linked to insomnia and restless sleep. Studies show that magnesium increases melatonin and decreases cortisol, helping regulate the sleep-wake cycle [7].

Muscle Recovery & Migraine Relief

Magnesium helps relax muscles and reduce cramping. It’s also effective in acute migraine treatment, with studies showing that IV magnesium sulfate can reduce migraine intensity and duration [9].

Energy Support & Fatigue Reduction

Magnesium is crucial for ATP production—your body’s energy currency. One study found that magnesium-deficient individuals had reduced exercise performance and faster onset of fatigue [10].

Who Might Benefit from Magnesium Infusions?

• Individuals with chronic fatigue, migraines, or muscle cramps

• People under high mental or physical stress

• Patients with gastrointestinal disorders or malabsorption

• Individuals with PMS, fibromyalgia, or chronic pain

• Athletes or active individuals needing post-workout recovery

How Often Are Magnesium Infusions Needed?

There’s no one-size-fits-all approach. Frequency may range from weekly to monthly, depending on your symptoms, lifestyle, and blood magnesium levels. Some people feel improvement after a single session, while others benefit from a regular infusion routine.

Final Thoughts

Magnesium is a foundational nutrient - and infusions can be a fast, effective way to restore balance, especially if you’re deficient or struggling with symptoms like fatigue, insomnia, or migraines. Backed by decades of clinical research, magnesium infusions offer more than just a wellness trend - they’re a science-driven solution to support your health at the cellular level.

Want to Feel the Benefits for Yourself?

Message us to find out if magnesium IV therapy is right for you. Your body - and your mind - may thank you. We’re located right here in Peterborough NH on Main Street, serving Peterborough and the monadnock region!

Simone Fyffe, RN

S. Fyffe RN Injections & Infusions LLC

References

1. de Baaij, J. H., Hoenderop, J. G., & Bindels, R. J. (2015). Magnesium in man: implications for health and disease. Physiological Reviews, 95(1), 1-46.

2. National Institutes of Health. Magnesium Fact Sheet for Health Professionals. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

3. Firoz, M., & Graber, M. (2001). Bioavailability of US commercial magnesium preparations. Magnesium Research, 14(4), 257–262.

4. Schuchardt, J. P., & Hahn, A. (2017). Intestinal absorption and factors influencing bioavailability of magnesium—an update. Current Nutrition & Food Science, 13(4), 260–278.

5. Spatling, L., & Classen, H. G. (1988). Intravenous magnesium in therapy. Magnesium Research, 1(2), 117–122.

6. Boyle, N. B., Lawton, C., & Dye, L. (2017). The effects of magnesium supplementation on subjective anxiety and stress: a systematic review. Nutrients, 9(5), 429.

7. Abbasi, B., et al. (2012). The effect of magnesium supplementation on primary insomnia in elderly: a double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences, 17(12), 1161–1169.

8. Zhang, X., et al. (2016). Effects of magnesium supplementation on blood pressure: a meta-analysis of randomized double-blind placebo-controlled trials. Hypertension, 68(2), 324–333.

9. Chiu, H. Y., et al. (2016). Effect of intravenous and oral magnesium on reducing migraine: a meta-analysis of randomized controlled trials. Pain Physician, 19(1), E97-E112.

10. Nielsen, F. H., Lukaski, H. C. (2006). Update on the relationship between magnesium and exercise. Magnesium Research, 19(3), 180–189.